I hear this question a lot and usually answer no. The resume should be a standard document that is really only updated when you have a new job, new duties, recent new achievements, or additional training/education. The magic of adaptation takes place in the cover letter. Even if not prompted, always submit a cover letter that specifically addresses the job at hand. You can put together a good boilerplate so you don’t always start with a blank page. This should include an introduction to you as a professional, specifically list your skills as they relate to the job requirements, and end with an offer to follow up with the company in the near future. By having this template at the ready, all you have to change is the date, recipient, and some specifics about the company requirements, but you will likely find that most of your target job descriptions are looking for similar qualities and experience.